| 化学表述 |
the polyaldehyde [(2R,4S,6R,8R,11S,13R)-1,14-dihydroxy-4-hydroxymethyl-3,5,7,10,12-pentaoxatetradecane-2,4,6,8,11,13-hexacarbaldehyde] derived from raffinose [β-D-fructofuranosyl α-D-galactopyranosyl-(1→6)-α-D-glucopyranoside] by treatment with sodium periodate is reacted with human hemoglobin A0 at the 2,3-DPG binding pocket. Both 55% is polymerised.intermolecular and intramolecular crosslinking occurs. This product is reduced to generate covalent amine bonds with >95% crosslinked hemoglobin of which about 55% is polymerised. |
